About Us

Advancing Molecular Interaction Research Through Integrated Biophysical & Computational Platforms

Creative Proteomics provides comprehensive molecular interaction analysis services — from real-time SPR kinetics and ITC thermodynamics to HDX-MS structural dynamics and in silico docking — supporting drug discovery, antibody characterization, and biomolecular mechanism research for pharmaceutical, biotechnology, and academic teams worldwide.

Discuss Your Project Explore Our Platforms

Label-Free Biophysics — SPR, BLI, MST, ITC

Structural Mass Spectrometry — HDX-MS, XL-MS, AP-MS

Proximity Labeling — BioID, TurboID, APEX

Computational Modeling — Docking, MD Simulation

Who We Are

Creative Proteomics is a contract research organization with nearly two decades of experience in analytical services for the life sciences. Through our molecular interaction analysis platform, we specialize in the characterization of biomolecular interactions — the fundamental binding events that drive biological function, disease mechanisms, and therapeutic action. Our team brings together biophysicists, biochemists, computational chemists, and mass spectrometrists to design integrated experimental strategies tailored to each research question.

We operate across a broad spectrum of complementary technologies — surface plasmon resonance (SPR), bio-layer interferometry (BLI), microscale thermophoresis (MST), isothermal titration calorimetry (ITC), hydrogen-deuterium exchange mass spectrometry (HDX-MS), cross-linking mass spectrometry (XL-MS), affinity purification mass spectrometry (AP-MS), proximity labeling (BioID/TurboID), pull-down assays, molecular docking, and molecular dynamics simulation. This multi-platform capability enables us to select the most appropriate technique — or combination of techniques — for each specific molecular system and research objective.

Our laboratory facilities for molecular interaction analysis

Our mission is to accelerate life science research and drug discovery by providing rigorous, transparent, and application-focused molecular interaction analysis services. High-quality binding data — generated on the appropriate platform, with validated controls, and reported with full experimental detail — provides the foundation for confident decision-making in target validation, lead optimization, and mechanism-of-action studies.

Research Applications We Support

Our molecular interaction analysis services span the full range of biomolecular research — from fundamental mechanism studies to industrial drug discovery programs. Each application area draws on a tailored combination of platforms selected to match the specific requirements of the experimental system and research objectives.

Drug Discovery & Lead Optimization

Fragment screening by SPR, hit validation by ITC and MST, kinetic characterization by BLI, and binding pose prediction by molecular docking. Support for covalent inhibitor characterization, PROTAC ternary complex analysis, and allosteric modulator studies.

Antibody & Biologics Characterization

Affinity (K_D) and kinetics (k_on/k_off) by SPR and BLI, epitope binning by SPR cross-competition, epitope mapping by HDX-MS, and aggregation and stability assessment by nanoDSF. Supporting mAb, bispecific, nanobody, and ADC programs.

Target Identification & Validation

AP-MS and BioID/TurboID for interactome mapping, XL-MS for complex topology, and SPR and ITC for target-ligand validation. Combined with molecular docking for structure-based target assessment and druggability analysis.

Protein-DNA/RNA & Nucleic Acid Interactions

EMSA and SPR for transcription factor-DNA binding, MST for RNA-protein affinity, ChiRP for chromatin-associated RNA analysis, and molecular dynamics for nucleic acid conformational sampling.

Signaling Pathway & Network Biology

PPI network mapping by AP-MS and XL-MS, kinase-substrate interaction analysis, GPCR-β-arrestin recruitment by SPR and BLI, and proximity labeling (BioID/TurboID) for subcellular interaction mapping in living cells.

Virus-Host & Immunology Research

Viral spike-ACE2 binding kinetics by SPR and BLI, antibody neutralization mechanism analysis by HDX-MS, cytokine-receptor interactions by MST, and virus-like particle (VLP) binding studies for vaccine development.

How We Support Your Research

Our workflow is structured to support molecular interaction research at every stage — from initial consultation through experimental design, data acquisition, and final reporting — ensuring each project receives the right combination of platforms and analytical depth.

Project Consultation

We begin by discussing your molecular system, research goals, sample characteristics, and key scientific questions. This initial assessment determines which platform — or integrated combination of platforms — is best suited to generate the data you need.

Experimental Design

Assay design is tailored to your specific system: surface chemistry selection for SPR, buffer optimization for ITC, deuteration time course design for HDX-MS, cross-linker selection for XL-MS, or docking grid definition for in silico studies. A detailed experimental plan is provided for your review before laboratory work begins.

Data Acquisition & Quality Control

All experiments are conducted with technique-specific controls and reference standards appropriate to each platform. Data pass through a multi-level quality review — spanning raw signal inspection, replicate consistency assessment, and control performance verification — before proceeding to analysis.

Analysis, Reporting & Discussion

Data are analyzed using fit-for-purpose kinetic and thermodynamic models. Every report includes raw data traces, analysis parameters, processed results, and a scientific interpretation section that contextualizes the findings within your research objectives.

Data Quality and Scientific Rigor

In molecular interaction analysis, data quality depends on experimental design, control strategy, data processing rigor, and reporting transparency. Our quality framework is built around four interconnected principles.

Instrument Performance Verification

All platforms undergo regular performance qualification. SPR and BLI instruments are verified with standard ligand-analyte pairs; ITC is validated with standard titration reactions; HDX-MS systems are checked with reference proteins. Qualification data is available for client review.

Assay-Specific Quality Controls

Every experiment includes controls matched to the technique: reference surface subtraction and blank injections for SPR and BLI, buffer-into-buffer control titrations for ITC, non-deuterated controls and back-exchange correction for HDX-MS, and non-cross-linked controls for XL-MS.

Rigorous Data Analysis Standards

Kinetic fitting uses appropriate binding models validated by residual analysis and chi-square statistics. ITC data are fitted with correct stoichiometry constraints. All analysis parameters and fitting decisions are documented in the final report alongside processed results.

Pre-Report Scientific Review

Before data delivery, each dataset undergoes peer review by a second scientist not directly involved in the project. This review evaluates experimental consistency, control performance, model selection, and the scientific plausibility of conclusions drawn from the data.

Data Security and Intellectual Property Protection

We recognize that molecular interaction studies frequently involve proprietary targets, unpublished compounds, and commercially sensitive data. Confidentiality and controlled information handling are integrated into every stage of our service workflow.

Confidential Project Initiation

All projects are initiated under structured confidentiality agreements. Technical discussions regarding molecular targets, compound structures, and experimental objectives are treated as confidential from the initial consultation.

Controlled Data Handling

Project files, raw data, processed results, and related communications are managed through access-controlled internal systems. Data storage and transfer use encrypted protocols throughout the project lifecycle.

Restricted Internal Access

Project information is shared internally on a need-to-know basis. Only scientists directly involved in the project have access to your data; other personnel within the organization do not.

Sample & Data Disposition

Upon project completion, remaining samples and data are handled according to your instructions — whether that involves secure long-term storage, return shipment, or verified destruction.

Our Partners & Collaborations

Over nearly two decades, Creative Proteomics has built trusted working relationships with leading research institutions, pharmaceutical companies, and biotechnology organizations worldwide. These collaborations span drug discovery programs, academic research initiatives, and multi-institutional projects across the life sciences.

Scientific Contributions

Molecular interaction analysis at Creative Proteomics has contributed to peer-reviewed research across a wide range of journals — from specialized structural and biophysical journals to high-impact multidisciplinary publications. The representative examples below span several of our core technology platforms.

Signal Transduction and Targeted Therapy IF 52.7

The AKAP12-PKA axis regulates lipid homeostasis during alcohol-associated liver disease

2025Crosslinking Proteomics (XL-MS)

Science Immunology

The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity

2024HDX-MS

International Journal of Molecular Sciences IF 4.9

Analyses of the MYBL1 Gene in Triple Negative Breast Cancer: Evidence of Regulation of the VCPIP1 Gene and Identification of a Specific Exon Overexpressed in Tumor Cell Lines

2024EMSA / Protein-DNA Interaction

PLoS One IF 2.6

Molecular and evolutionary determinants for protein interaction within a class II aldolase/Adducin domain

2025Molecular Dynamics Simulation

BMC Molecular Biology

Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein

2016Pull-Down + Mass Spectrometry

Why Researchers Choose Creative Proteomics

Researchers in the pharmaceutical, biotechnology, and academic sectors partner with Creative Proteomics for molecular interaction analysis because of our multi-platform capability, scientific depth, and commitment to transparent data reporting.

Multi-Platform Integration Under One Roof

Our laboratory operates more than ten technology platforms for molecular interaction analysis, enabling complementary approaches — SPR kinetics combined with HDX-MS structural mapping, or ITC thermodynamics integrated with in silico docking — to address complex binding questions through orthogonal methods.

Application-Focused Experimental Design

Each project is designed around the specific biological question and molecular system under study. Platform selection, assay conditions, and control strategies are determined by the scientific requirements of the project.

Rigorous Data Quality & Transparent Reporting

Data integrity is built into our workflow, not inspected in afterward. Every deliverable includes primary data traces, full experimental conditions, and analysis parameters — so your team can evaluate the evidence directly, meet journal data transparency requirements, and reproduce findings independently.

Responsive Scientific Communication

Every project is assigned a dedicated lead scientist who serves as a single point of contact throughout the study. This ensures that questions about experimental design, preliminary data, or results interpretation are answered by someone who knows your project — not a rotating support desk. Regular updates at key project milestones keep you informed of progress without requiring you to chase status.

A Collaborative Approach to Research Support

We work as an extension of your research team — from initial consultation and experimental design through data interpretation and publication support. Our objective is to deliver data and analysis that directly advance your research program.

Who We Serve

We partner with research organizations of all sizes — from biotechnology startups to global pharmaceutical companies, from individual academic laboratories to large-scale government research programs. Our services are structured to accommodate different project scales, timelines, and analytical depth requirements.

Pharmaceutical Companies

Supporting drug discovery pipelines from target identification through lead optimization. SPR fragment screening, ITC hit validation, BLI kinetic profiling, HDX-MS epitope mapping, and PROTAC ternary complex characterization for small molecule and biologic programs.

Biotechnology Companies

Flexible analytical support for early-stage programs with evolving requirements. Rapid turnaround for antibody characterization, platform selection guidance, and scalable experimental design that adapts as your pipeline advances.

Academic Institutions

Research-oriented services for mechanistic studies, structural biology projects, and publication-quality data. Support for grant application preliminary data, experimental design consultation, and detailed methods documentation for manuscript preparation.

Government & Research Organizations

Structured analytical support for large-scale research initiatives, translational programs, and multi-institutional collaborations. Experience with government contracting requirements, milestone-based reporting, and data security protocols.