Antibodies are an important component of the immune system. They are glycoproteins produced by B cells that can bind to antigens such as viruses, bacteria, and cancer cells, and neutralize or label them for destruction by other immune cells. Antibodies have different structures, affinities, and specificities, allowing them to recognize and respond to a wide range of antigens. However, to use antibodies for diagnostic, therapeutic, or research purposes, it is necessary to determine the precise epitopes on the antigen that the antibody binds to. This is where antibody epitope mapping comes in.
Antibody epitope mapping is the process of identifying and characterizing specific regions or sites on an antigen that are recognized and bound by antibodies. This information can be used to design better vaccines, diagnostic assays, or antibody-based therapies, as well as to understand the molecular basis of antibody-antigen interactions.
Epitope mapping on the 3D structure (Leoni et al., 2019)
At Creative Proteomics, we offer a range of services for antibody epitope mapping, including peptide scanning, targeted mutagenesis, hydrogen-deuterium exchange mass spectrometry, X-ray crystallography, NMR spectroscopy, and computational modeling. Our team of experienced biologists, chemists, and bioinformaticians can help you identify and characterize antibody epitopes with high precision and accuracy. Whether you are conducting basic research, designing vaccines or optimizing antibody-based therapies, we can provide you with the insights and solutions you need to succeed.
Epitope Mapping of Polyclonal Antibodies by HDX-MS (Stander et al., 2021)
Our services are provided with the highest standards of quality, reliability, and confidentiality and are backed by a dedicated team of experts committed to providing personalized and responsive support. With our comprehensive antibody epitope mapping service, you can be sure that you will receive the most accurate and detailed information about your antibody, enabling you to make informed decisions about your development program.