Drug-Drug Interactions

Drug-Drug Interactions

Background

When multiple drugs are taken at the same time, unexpected drug-drug interaction (DDI) may occur between the drugs. The effects of DDI on treatment can be harmful or beneficial. Harmful DDI can reduce the drug efficacy, cause serious side effects, and even increase toxicity; on the other hand, beneficial DDI can enhance efficacy, synergistic drug combinations have been successfully applied in the treatment of complex diseases such as cancer and AIDS.

At present, only a small amount of DDIs were identified in the experimental stage, and most DDIs were discovered through clinical data feedback from patients after the drug was on the market. Due to the serious consequences of improper combination medication, such as the occurrence of medical accidents and the delisting of certain drugs (mibefradil, astemizole, etc.), combination medication has attracted more and more attention, the need for research on DDI before listing is becoming urgent, which is of great significance for improving the safety of clinical combination drugs, the development of new drugs, and the improvement of people's quality of life.

Side effects of drug-drug interactions - Creative ProteomicsFig 1. Side effects of drug-drug interactions - Creative Proteomics

Services

Creative Proteomics focuses on the study of drug-drug interactions and has established a technology platform to help customers fully understand its mechanism of action. We use scientific and reliable research methods (such as HPLC-MS-MS, HPLC-MS-NMR, pharmacokinetic-pharmacodynamic modeling, etc.), powerful data analysis tools, and II/III clinical trials data, to conduct comprehensive analyses of DDI.  

Besides, we also provide time-saving, low-cost computer-based predictive analysis, including similarity-based prediction methods and scientific literature-based methods. At present, Creative Proteomics is still developing new technologies to study the pharmacokinetics and pharmacodynamic characteristics of drugs, so as to fully, rationally, scientifically and effectively exert the maximum efficacy of drugs.

Customers can choose a certain technology according to the needs of the project, or contact us directly for consultation, and our expert team will provide you with a customized experimental program.

Applications

  • Drug-drug interaction research  
  • Pharmacokinetics and pharmacodynamics research
  • Safety research of combination drugs
  • New drug development

Highlights

  • Numerous advanced technologies
  • Combination of experimental and calculation methods
  • Accurate and reliable data
  • Continuously updated technology platform

Creative Proteomics has provided high-quality drug-drug interaction analysis services to lots of customers from all over the world. Based on our excellent technology platform, customers can obtain highly accurate experimental and predictive data to greatly accelerate the process of project research. We are honored to be your competent research assistant.

Reference

  1. Guieu, B.; et al. Desirable drug-drug interactions or when a matter of concern becomes a renewed therapeutic strategy. Drug Discovery Today. 2020.
* This service is for RESEARCH USE ONLY, not intended for any clinical use.