Cell-Cell Interactions in Tumor Microenvironment Analysis


Cell-cell interaction is critical to the development and function of multicellular organisms. In addition, the cell-cell interaction is also affected by its physiological environment, including the physical and the biochemical properties of the extracellular matrix, such as nutrient level and oxygen level, etc. These cell interactions drive many physiological processes, help achieve coordination in multicellular organisms, and organize cell behavior and complex biological functions.

Cancer is one of the main causes of death in the world. Tumor tissue is not only composed of cancer cells, 50% of which may be non-cancerous cells and non-cellular components. The diversity of these interactions together promotes the occurrence and progression of cancer. Therefore, understanding the cell-cell interactions in the tumor microenvironment (TME) can not only provide in-depth understanding of oncology, but also provide new ideas for the development of new therapies, but these interaction networks are extremely complex, the research on them is challenging.

Features of the tumor microenvironmentFig 1. Features of the tumor microenvironment (Lyssiotis, C.A.; Kimmelman, A.C. 2017)


Creative Proteomics integrates many advanced technologies to clarify cell-cell interactions in the complex tumor microenvironment, and each method has advantages and disadvantages. In this platform, we combine multiple technologies to minimize limitations and improve accuracy. The platforms we provide include but are not limited to the following technologies.

  • Imaging

Including fixed tissue imaging and live tissue imaging, these technologies can visually observe cell-cell interactions with limited quantitative characteristics and throughput. Currently, Creative Proteomics has introduced new technologies, such as imaging-based mass spectrometry (IMS) and Raman microscopy (RM) to help customers better study cell-cell interactions.

Analysis at the molecular level has strong advantages, but the spatial and structural effects of cell-cell interactions will be lost.

It has been widely used to describe the heterogenous populations in complex organizations.

Customers can choose a certain technology according to the needs of the project, or contact us directly for consultation, and our expert team will provide you with a customized experimental program.


  • Cell-cell interaction research
  • Research on the physiological system of multicellular organisms
  • Tumor microenvironment research
  • Research on the occurrence and progression of cancer


  • High resolution and high accuracy   
  • Capable of spatial distribution analysis and high-throughput analysis
  • Highly sensitive laboratory equipment
  • Powerful data analysis tools
  • Cost-effective

The study of cell-cell interactions in the tumor microenvironment is essential for us to develop new generation of cancer therapies. Creative Proteomics has been focusing on this field for decades and has built a platform that combines a variety of advanced technologies to provide customers with high-quality analysis services. We are honored to be your competent research assistant.


  1. Nishida-Aoki, N.; Gujral, T.S. Emerging approaches to study cell-cell interactions in tumor microenvironment. Oncotarget. 2019, 10(7): 785-797.
  2. Lyssiotis, C.A.; Kimmelman, A.C. Metabolic interactions in the tumor microenvironment. Trends Cell Biol. 2017, 27.
* This service is for RESEARCH USE ONLY, not intended for any clinical use.