Protein-Protein Interactions

Protein-Protein Interactions


Protein is not an isolated biological molecule, but has a specific three-dimensional structure and interacts with other molecules (proteins, metabolites, lipids and nucleic acids) to perform functions together, such as mediating signal transduction, regulating metabolism, and energy conversion, etc. Therefore, the modularity and spatial organization of proteins are as important as their expression levels.

Proteins form a complex network by interacting with other proteins, and form a highly organized and dynamic cell system. The research of PPI is helpful to our research on diseases and the development of new drugs. In recent years, in order to analyze PPI, many research methods in vivo, in vitro and in silico have been developed, paving the way for a more comprehensive and systematic study of PPI in the future.

The protein-protein complex structure between Xiap-BIR3 (surface) and Caspase (ribbon)Fig 1. The protein-protein complex structure between Xiap-BIR3 (surface) and Caspase (ribbon) (Rosell, M.; Fernández-Recio, J. 2018)



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Protein-protein interaction is the basis of many life activities, so the research enthusiasm for PPI has not diminished.Creative Proteomics began to establish PPI analysis platforms more than ten years ago, which includes a large number of excellent technologies and methods that can help customers study PPI in vivo, in vitro and in silico. We are honored to be your competent research assistant.


  1. Braun, P.; Gingras, A.C. History of protein-protein interactions: From egg-white to complex networks. PROTEOMICS. 2012: 1478-1498.
  2. Rosell, M.; Fernández-Recio, J. Hot-spot analysis for drug discovery targeting protein-protein interactions. Expert Opinion on Drug Discovery. 2018, 134(4).
* This service is for RESEARCH USE ONLY, not intended for any clinical use.