Infectious disease agents such as bacteria, fungi, viruses, and parasites cause approximately 15 million deaths worldwide, among which human immunodeficiency virus (HIV) and acute respiratory infections are the main causes. Viruses are the smallest known microorganisms, but they can pose a major challenge to the health of millions of people and have a negative impact on the socio-economic development of the world.
The development or application of particles whose size falls into the nanometer range (10-9 or one billionth of a meter) is called nanotechnology. The interaction between nanoscience and biological systems is called nanobiotechnology, and it can prevent, diagnose, and treat diseases.
Nanoparticles can exert their antiviral activity through a variety of mechanisms, mainly due to its unique properties, including (1) large surface area to volume ratio (ensures large drug payloads can be accommodated), (2) small particle size (promote drug delivery to specific sites), (3) Tunable surface charge (facilitate the crossing of cell membranes) (4) biomimetic properties with inherent antiviral properties, (5) engineered nanoparticles can improve the specificity to targeted cells and greatly improve drug delivery.
Fig 1. Various types of nanoparticles used for antiviral therapy as antiviral agents and delivery agents (Gurunathan, S.; et al. 2020)
Creative Proteomics has been focusing on nanobiotechnology for more than ten years, and we have provided high-quality technical services to many scientists from all over the world. We recruited a large number of experts in virology, material science, biochemistry and other fields to establish a comprehensive and systematic virus-nanoparticle interaction research platform, the platform includes transmission electron microscope (TEM), ultraviolet-visible spectroscopy, etc., which can characterize the size, shape, distribution and other parameters of nanoparticles; and high-angle annular dark-field imaging (HAADF), etc., can obtain clear images of virus-nanoparticle interaction. We also provide a large number of sample processing methods to ensure that weak interactions can also be detected and analyzed.
Fig 2. a. HAADF image of an HIV-1 virus exposed to BSA-conjugated silver nanoparticles. b. HAADF image of HIV-1 viruses without silver nanoparticle treatment (Elechiguerra, J.L.; et al. 2005)
Customers can choose a certain technology according to the needs of the project, or contact us directly for consultation, and our expert team will provide you with a customized experimental program.
Creative Proteomics is an international biotechnology company dedicated to helping customers speed up research and improve research quality. We have integrated talents from multiple fields to form a strong technical team, and also set up a platform with a variety of advanced technologies to help customers complete their research projects with high quality. We are honored to be your competent research assistant.