Circular Dichroism (CD)

Circular Dichroism (CD)

Introduction

Since the discovery of circular dichroism by Jean-Baptiste Biot, Augustin Fresnel, and Aimé Cotton in the last century, the phenomenon has been widely used in various fields. Circular dichroism (CD) is the difference in absorption of left-handed circularly polarized light (L-CPL) and right-handed circularly polarized light (R-CPL), occurs when a molecule contains one or more chiral chromophores (light absorbing groups).

Different structural elements present specific CD spectra, so the use of this technology to measure the CD produced by specific molecules within a certain wavelength range can be applied to many fields. Its applications include: studying chiral molecules of various types and sizes; exploring the secondary structure/conformation of macromolecules; obtaining kinetic and thermodynamic information, such as how the secondary structure changes with environmental conditions or the interactions with other molecules.

Figure 1. Schematic representation of the Circular Dichroism instrument configurationFigure 1. Schematic representation of the Circular Dichroism instrument configuration (Pignataro, M.F.; et al.)

Our Services

Circular Dichroism (CD) Platform

Creative Proteomics is professional experts in the application of circular dichroism. We have introduced many advanced spectroscopy equipment, including circular dichroism spectroscopy, variable temperature circular dichroism, magnetic circular dichroism, and high-sensitivity polarimetry, etc. The technology platform is managed by experienced experts and is regularly upgraded to enhance performance. Our scientists can provide customers with one-stop circular dichroism services, ranging from small chiral drugs and transition metal complexes to the structure and interaction of biological macromolecules (such as proteins, glycoproteins, and nucleic acids).

It is worth mentioning that we have developed algorithms with higher reliability, as well as objective methods for comparing spectra, which can be used for unbiased comparative studies of biopharmaceuticals and biosimilars.

Highlights

  • A variety of spectrum facilities
  • Data can be directly used for article publication
  • Customized services according to the specific needs of customers
  • Cost-effective

Customers can choose different technology platforms according to project requirements, or contact us directly for consultation, and our expert team will provide you with customized experimental procedures.

Creative Proteomics is an international biotechnology company dedicated to research in molecular interactions and other related fields. The circular dichroism platform we constructed has the characteristics of high sensitivity and efficiency, and the data obtained can be directly used for article publication. Our one-stop service aims to save customers time and money.

Reference

  1. Pignataro, M.F.; et al. Evaluation of Peptide/Protein Self-Assembly and Aggregation by Spectroscopic Methods. Molecules. 2020.
* This service is for RESEARCH USE ONLY, not intended for any clinical use.

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