DNA/RNA-Graphene Interactions

DNA/RNA-Graphene Interactions

Background

Graphene is an emerging magical material, it is an allotrope of carbon consisting of a single layer of atoms arranged in a two-dimensional honeycomb lattice. In 2004, physicists Andre Geim and Konstantin Novoselov at the University of Manchester successfully separated graphene from graphite in experiments and confirmed that it can exist alone, people's interest in this material has increased exponentially. Graphene and its derivatives exhibit many superior physical, chemical and mechanical properties due to the unique combination of crystallographic and electronic structure, and have shown attractive potential in the fields of biosensing, disease diagnosis, and drug screening, etc.

Molecules, biomolecules, polymers, and even nanoparticles can be loaded/bonded onto graphene carriers. In the past few years, the coupling of nucleic acids to graphene-based materials has attracted more attention. Because nucleic acid is stable, easy to modify, and can recognize multiple targets with high selectivity and affinity, nucleic acid-interfacial graphene can greatly improve the recognition ability and biocompatibility characteristics.

Nucleic acid-graphene interfaceFig 1. Nucleic acid-graphene interface (Saravanan, V.; et al. 2020)

Services

Creative Proteomics integrates internationally commonly used and emerging technologies to form a unique nucleic acid-graphene interaction research platform, and has formed a team with expertise in graphene to provide consulting and overall solutions for customers' project research. Our platform includes but is not limited to the following technologies.

  • Physical techniques

Physical techniques including transmission electron microscopy (TEM), atomic force microscopy (AFM), scanning tunneling microscopy (STM) and X-ray diffraction (XRD) can characterize the structure and chemical properties of the nucleic acid-graphene interface.

  • Optical techniques

Fluorescence is a highly sensitive technology for studying the graphene-nucleic acid biological interface. We provide fluorescence spectroscopy and fluorescence resonance energy transfer (FRET) technique.

  • Electrochemical techniques

Due to its excellent electronic conductivity and electrocatalytic activity, cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and electrochemiluminescence (ECL) can be used to study the nucleic acid-graphene interface.

Customers can choose a certain technology according to the needs of the project, or contact us directly for consultation, and our expert team will provide you with a customized experimental program.

Applications

  • Biosensor development
  • Small molecule/protein detection
  • Gene delivery and therapy
  • DNA sensing/sequencing
  • Cell imaging
  • Drug delivery

Highlights

  • High sensitivity¬†
  • Combine numerous technologies
  • Tailored experimental program
  • High accuracy and repeatability of experimental results

Creative Proteomics has a mature and advanced nucleic acid-graphene interaction research platform, and will constantly upgrade it to ensure that we can provide customers with accurate, sensitive and high-quality experimental results. We are honored to be your competent research assistant.

References

  1. Tang, L.H.; et al. The graphene/nucleic acid nanobiointerface. Chem. Soc. Rev. 2015.
  2. Saravanan, V.; et al. Exploring the nature of interaction and stability between DNA/RNA base pairs and defective & defect-dopant graphene sheets. A possible insight on DNA/RNA sequencing. International Journal of Biological Macromolecules. 2020.
* This service is for RESEARCH USE ONLY, not intended for any clinical use.