Sum Frequency Generation (SFG) Vibrational Spectroscopy

Sum Frequency Generation (SFG) Vibrational Spectroscopy


Graphene has become a hot research topic, and its application has been extended to the areas of nano-biotechnology, such as nano-biomedicine, nano-biosensing, and nano-electronics, etc. These applications involve the interaction between proteins, peptides, DNA, RNA and graphene, so understanding such molecular interactions is crucial for the further research of graphene.

A variety of techniques have been developed for surface characterization, including scanning electron microscopy (SEM), tunneling electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS), but they all require high vacuum during operation, which limits the application of these technologies. Sum Frequency Generation (SFG) vibrational spectroscopy is similar to Raman spectroscopy, it can provide a variety of information about molecular functional groups at the surface or interface. Moreover, SFG can study various interfaces, including liquid-liquid, solid-solid, and liquid-solid interfaces. SFG has a wide range of applications, including materials science (polymers, electrochemistry) and life sciences (membrane, biological materials), etc. Due to its high surface/interface selectivity and versatility, it is becoming a highly potential tool in surface scientific research.


Creative Proteomics established the SFG technology platform many years ago. The platform is managed by experienced technicians and aims to provide high-quality services on surface science to researchers all over the world. We provide sum frequency generation (SFG) vibrational spectroscopy and molecular dynamics (MD) simulation, circular dichroism (CD) spectra and other related technologies to help customers monitor the binding process of substances to graphene in real time, and characterize the substances bound to graphene (For example, the conformation and orientation of peptides).

Customers can choose different technology platforms according to project requirements, or contact us directly for consultation, and our expert team will provide you with customized experimental procedures.

Creative Proteomics is an international biotechnology company dedicated to research in molecular interactions and other related fields. The sum frequency generation vibrational spectroscopy platform we constructed has the characteristics of high quality and efficiency, and the data obtained can be directly used for paper publication. Our one-stop service aims to save customers time and money.


  1. Zou, X.; et al. Molecular Interactions between Graphene and Biological Molecules. Journal of the American Chemical Society. 2017.
  2. Ulrich, N.W.; et al. Surface Analysis | Sum Frequency Generation Spectroscopy. Encyclopedia of Analytical Science. 2019.
* This service is for RESEARCH USE ONLY, not intended for any clinical use.

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