Natural Product-Drug Interactions

Natural Product-Drug Interactions

Background

Currently, the sales of botanical dietary supplements and other medicinal natural products (NPs) are on the rise, which greatly increases the possibility of significant pharmacokinetic interactions between NPs and drugs approved by the Food and Drug Administration. Therefore, when patients regularly take NPs with other drugs, it is very likely that natural product-drug interactions (NPDIs) will change the efficacy and safety of traditional drugs.

However, due to the batch heterogeneity of natural products, the lack of relevant pharmacokinetic information, and the complexity of their interactions, evaluating NPDI is more challenging than drug-drug interactions. As NPDI is affecting people's quality of life, it is becoming more and more urgent to develop systematic experimental methods and calculation methods to guide researchers to conduct NPDI research correctly.

Unknown interactions between natural products and drugs - Creative ProteomicsFig 1. Unknown interactions between natural products and drugs - Creative Proteomics

Services

In order to meet these challenges, Creative Proteomics formed a multidisciplinary team of medicinal chemists, natural product chemists, clinical pharmacologists, bioinformatician, etc., through biochemical technology, analytical chemistry technology, computer modeling and simulation, and the analysis of human clinical research data to simulate and evaluate these complex natural product-drug interactions. The services we provide include but are not limited to the following aspects.

  • Identify, characterize, and quantify the chemical components present in natural products.
  • Assess the similarities and differences between natural chemical components.
  • Measure natural product binding (fu plasma, fu mic), inhibition potency (IC50, Ki), metabolism and transport (Vmax, Km), and induction potential (EC50, Emax), and other parameters.
  • Establish mathematical models to reliably predict the interactions between natural products and drugs.

Customers can choose certain services according to project requirements, or contact us directly for consultation, and our expert team will provide you with a customized experimental program.

Applications

  • Natural product-drug interaction research 
  • Research on the Mechanism of Action of Natural Products
  • Research on the efficacy and safety of natural products
  • Adverse drug reaction research
  • Method development for NPDI

Highlights

  • Multidisciplinary integration
  • High precision and high sensitivity
  • Data can be directly used for article publication
  • Experienced and well-trained technicians
  • One-stop service

Creative Proteomics has formed a multidisciplinary team of experts, combined with our advanced technology platform, can provide customers with a variety of reliable parameters and rational computer predictions on natural product-drug interaction studies, so as to greatly accelerate the progress of the project. We are honored to be your competent research assistant.   

References

  1. Paine, M.F.; et al. Recommended approaches for pharmacokinetic natural product-drug interaction research: a NaPDI center commentary. Drug Metabolism and Disposition. 2018.
  2. Romano, J.D.; Tatonetti, N.P. Informatics and computational methods in natural product drug discovery: a review and perspectives. Front. Genet. 2019.
* This service is for RESEARCH USE ONLY, not intended for any clinical use.