Currently, the sales of botanical dietary supplements and other medicinal natural products (NPs) are on the rise, which greatly increases the possibility of significant pharmacokinetic interactions between NPs and drugs approved by the Food and Drug Administration. Therefore, when patients regularly take NPs with other drugs, it is very likely that natural product-drug interactions (NPDIs) will change the efficacy and safety of traditional drugs.
However, due to the batch heterogeneity of natural products, the lack of relevant pharmacokinetic information, and the complexity of their interactions, evaluating NPDI is more challenging than drug-drug interactions. As NPDI is affecting people's quality of life, it is becoming more and more urgent to develop systematic experimental methods and calculation methods to guide researchers to conduct NPDI research correctly.
Fig 1. Unknown interactions between natural products and drugs - Creative Proteomics
In order to meet these challenges, Creative Proteomics formed a multidisciplinary team of medicinal chemists, natural product chemists, clinical pharmacologists, bioinformatician, etc., through biochemical technology, analytical chemistry technology, computer modeling and simulation, and the analysis of human clinical research data to simulate and evaluate these complex natural product-drug interactions. The services we provide include but are not limited to the following aspects.
Customers can choose certain services according to project requirements, or contact us directly for consultation, and our expert team will provide you with a customized experimental program.
Creative Proteomics has formed a multidisciplinary team of experts, combined with our advanced technology platform, can provide customers with a variety of reliable parameters and rational computer predictions on natural product-drug interaction studies, so as to greatly accelerate the progress of the project. We are honored to be your competent research assistant.