Dynamic Light Scattering (DLS)

Dynamic Light Scattering (DLS)

Introduction

Dynamic Light Scattering (DLS) is a mature biophysical technology that can accurately characterize the particle size in suspensions and emulsions. This technology has been widely recognized in the pharmaceutical and industrial world. DLS technology optically measures motion by recording the scattered light signals at a fixed angle. The particles are illuminated with a monochromatic coherent light source and the light scattered by the particles is recorded.

It is based on the Brownian motion, that is, in simple terms, small particles move/spread faster than large particles. The light scattered by the particles contains information about the speed of diffusion and therefore also information about the size distribution. It can measure highly concentrated and highly diluted samples, as well as parameters such as Zeta potential, molecular weight, and concentration.

With DLS, the aggregation behavior of compounds, proteins, or protein-ligand binding complexes can be characterized. The correlation between time points can be used to determine the radii of nanometer-scale objects in solution.

Figure 1. Scheme of a light scattering setupFigure 1. Scheme of a light scattering setup (Falke, S.; Betzel, C. 2019)

Our Services

Creative Proteomics introduced an advanced dynamic light scattering technology platform to provide scientific research assistance to researchers in various fields. We have recruited many professional DLS technicians to offer customers strong support throughout the process, especially the most critical sample preparation and data collection steps.

Dynamic Light Scattering (DLS) Platform

Capabilities

  • Hydrodynamic radius and size distribution (~1nm – 10um)
  • Critical micelle concentration
  • Gelation/Aggregation/Creaming/Sedimentation

Highlights

  • Accurate, repeatable, and fully automatic
  • Able to measure extremely small particles
  • Able to measure zeta potential
  • Low volume requirements
  • Compliance with regulatory standards

Our experienced analysts will discuss whether your samples and projects are suitable for DLS analysis, and how this analysis technique can provide additional answers to your project. Customers can choose different technology platforms according to project requirements, or contact us directly for consultation, and our expert team will provide you with customized experimental procedures.

Creative Proteomics is an international biotechnology company dedicated to research in molecular interactions and other related fields. The DLS platform we constructed has the characteristics of high sensitivity and efficiency, and the data obtained can be directly used for article publication. Our one-stop service aims to save customers time and money.

* This service is for RESEARCH USE ONLY, not intended for any clinical use.

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