Protein-Graphene Interactions

Protein-Graphene Interactions

Background

At present, graphene materials have attracted widespread attention in the field of biomedicine due to their excellent physical and chemical properties and broad application prospects. When graphene materials are used in biological applications (such as drug delivery, biosensing, and bioimaging), they will inevitably interact with various proteins and cause changes in their characteristics as well as protein configuration and function. This process is considered to be the beginning of graphene materials entering the living system.

Therefore, a lot of studies have been carried out on the interaction between graphene materials and protein molecules, which can help us analyze the sites and mechanisms of the interactions at the molecular level, this is of great significance for assessing its potential toxicity in living systems, and provides an extremely important basis and guidance for the design and development of high-efficiency non-toxic graphene materials.

Interactions between graphene materials and proteinsFig 1. Interactions between graphene materials and proteins (Zuo, G.; et al. 2011)

Services

Creative Proteomics provides conventional analysis methods including infrared (IR) spectroscopy, photoluminescence (PL) spectroscopy, electrochemical methods and calculation methods including molecular dynamics simulations to help customers study protein-graphene interactions.

At the same time, we also provide quartz-crystal microbalance with dissipation monitoring (QCM-D), which is an evaluation method that can provide qualitative information (including the dynamics and structural properties of bound proteins). QCM-D is a real-time monitoring system based on the piezoelectric properties of AT-cut quartz crystals. Real-time monitoring of changes in resonant frequency and damping with high resolution can analyze the mass adsorption, adsorption mechanism, thickness, and structural conformation of biomolecules on the crystal surface. This novel platform can be used to monitor biochemical events, as well as an effective way to develop graphene-based biosensors.

Customers can choose a certain technology according to the needs of the project, or contact us directly for consultation, and our expert team will provide you with a customized experimental program.

Applications

  • Protein-graphene interaction research
  • Graphene material optimization
  • Biosensor development
  • Drug delivery system development
  • Bioimaging

Highlights

  • Combination of multiple technologies
  • Combination of experimental methods and calculation methods
  • High sensitivity and high accuracy
  • Data can be directly used for article publication
  • Experienced research team

Graphene has attracted more and more attention as an excellent biomedical material. In order to assist customers in exploring protein-graphene interactions, Creative Proteomics has developed a large number of advanced technical tools and experimental methods for quantitative and qualitative analysis, which helps customers save time and effort while obtaining accurate data. We are honored to be your competent research assistant.

References

  1. Zou, X.; et al. Molecular Interactions between Graphene and Biological Molecules. Journal of the American Chemical Society. 2017, 139(5): 1928-1936.
  2. Zuo, G.; et al. Adsorption of Villin Headpiece onto Graphene, Carbon Nanotube, and C60: Effect of Contacting Surface Curvatures on Binding Affinity. The Journal of Physical Chemistry C. 2011, 115(47): 23323-23328.
* This service is for RESEARCH USE ONLY, not intended for any clinical use.